| Temporada | Equipo | Competición | PJ | G | A | Nota | ||
|---|---|---|---|---|---|---|---|---|
| 2025/2026 | Johor DT | Super League | 3 | 0 | 0 | 0 | 0 | – |
| 2023/2024 | Sassuolo | Serie A | 17 | 0 | 0 | 2 | 0 | 6.6 |
| 2022/2023 | Valencia | LaLiga | 25 | 4 | 0 | 7 | 0 | 6.8 |
| 2021/2022 | AC Milan | Serie A | 5 | 0 | 0 | 0 | 0 | 6.8 |
| 2020/2021 | AC Milan | Serie A | 28 | 1 | 0 | 5 | 0 | 6.7 |
| 2019/2020 | AC Milan | Serie A | 22 | 2 | 3 | 3 | 0 | 6.9 |
| 2018/2019 | AC Milan | Serie A | 31 | 4 | 2 | 3 | 0 | 6.8 |
| 2017/2018 | Villarreal | LaLiga | 30 | 6 | 5 | 4 | 0 | 7.0 |
| 2016/2017 | Villarreal | LaLiga | 33 | 2 | 3 | 2 | 0 | 6.8 |
| 2015/2016 | Villarreal | Primera Division | 28 | 1 | 1 | 4 | 0 | – |
| 2014/2015 | Malaga | Primera Division | 34 | 1 | 5 | 5 | 0 | – |
| Total | 256 | 21 | 19 | 35 | 0 | – | ||
| Fecha | Desde | Hacia | Tipo | |
|---|---|---|---|---|
| - | Valencia | Johor DT | Free agent | |
| - | Sassuolo | Valencia | Return from loan | |
| 09 ene 2023 | Valencia | Sassuolo | Loan | |
| 07 dic 2022 | AC Milan | Valencia | Free agent | |
| - | Villarreal | AC Milan | Transfer | |
| 07 ene 2015 | Malaga | Villarreal | Transfer |
S. Castillejo career history shows progression across clubs and competitions, including club timeline, national team appearances and overall career totals.