| Temporada | Equipo | Competición | PJ | G | A | Nota | ||
|---|---|---|---|---|---|---|---|---|
| 2024 | Independiente Rivadavia | Liga Profesional Argentina | 1 | 0 | 0 | 0 | 0 | 6.3 |
| 2023 | Universidad Católica | Primera División | 20 | 2 | 1 | 1 | 0 | 6.7 |
| 2022/2023 | Tijuana | Liga MX | 15 | 2 | 0 | 1 | 0 | 6.7 |
| 2021/2022 | Göztepe | Süper Lig | 15 | 3 | 0 | 3 | 0 | 6.8 |
| 2021 | San Lorenzo | Liga Profesional Argentina | 27 | 10 | 1 | 4 | 0 | 7.0 |
| 2020/2021 | San Lorenzo | Liga Profesional Argentina | 6 | 0 | 0 | 0 | 0 | 6.6 |
| 2020 | Atlético Mineiro | Mineiro 1 | 6 | 3 | 0 | 0 | 0 | – |
| 2019 | Atlético Mineiro | Serie A | 21 | 3 | 1 | 2 | 0 | 6.8 |
| 2018/2019 | Rayo Vallecano | La Liga | 6 | 0 | 0 | 1 | 1 | 6.5 |
| 2018/2019 | Schalke 04 | Bundesliga | 4 | 0 | 0 | 0 | 0 | 7.0 |
| 2017/2018 | Schalke 04 | Bundesliga | 30 | 3 | 1 | 4 | 0 | 6.7 |
| 2016/2017 | Schalke 04 | Bundesliga | 12 | 0 | 2 | 2 | 0 | 6.7 |
| 2015/2016 | Schalke 04 | Bundesliga | 25 | 2 | 1 | 3 | 0 | 6.7 |
| 2014/2015 | Werder Bremen | Bundesliga | 26 | 13 | 0 | 8 | 0 | – |
| 2013/2014 | Werder Bremen | Bundesliga | 23 | 4 | 0 | 6 | 1 | – |
| 2012/2013 | Wigan Athletic | Premier League | 35 | 5 | 0 | 5 | 0 | – |
| 2011/2012 | Wigan Athletic | Premier League | 32 | 7 | 0 | 4 | 0 | – |
| 2010/2011 | Wigan Athletic | Premier League | 25 | 1 | 0 | 2 | 0 | – |
| 2009/2010 | Blackburn Rovers | Premier League | 22 | 1 | 0 | 3 | 0 | – |
| 2008/2009 | Chelsea | Premier League | 8 | 0 | 0 | 0 | 0 | – |
| 2007 | Audax Italiano | Primera División | 37 | 7 | 0 | 0 | 0 | – |
| 2006 | Audax Italiano | Primera División | 24 | 7 | 0 | 0 | 0 | – |
| Total | 420 | 73 | 7 | 49 | 2 | – | ||
| Fecha | Desde | Hacia | Tipo | |
|---|---|---|---|---|
| 02 mar 2024 | Univ Católica | Independiente | Free | |
| 01 jul 2023 | Tijuana | Univ Católica | Free | |
| - | Göztepe | Tijuana | Free | |
| - | San Lorenzo | Göztepe | Free | |
| - | Atlético MG | San Lorenzo | Free | |
| 08 feb 2019 | Vallecano | Atlético MG | Free | |
| - | Schalke | Vallecano | Free | |
| - | Bremen | Schalke | € 6M | |
| - | Wigan | Bremen | Free | |
| 08 abr 2009 | Chelsea | Blackburn | Loan | |
| 08 ene 2008 | Audax | Chelsea | € 4.5M |
F. Di Santo career history shows progression across clubs and competitions, including club timeline, national team appearances and overall career totals.